Tablet Disintegration Testers

DTGi Series features 1, 2, 3 and 4 station units as well as a 2-station independent control unit, ideal for testing under varying conditions. The new DTGi Series are an affordable method of testing disintegration, suitable for a wide range of tablet and capsule types e.g. plain-coated tablets, delayed-release, gelatine etc.

  • Eur. and USP compliant
  • Integrated, precision temperature control measurement
  • Option to automate and remotely control DTGi systems
  • Adjustable stroke frequency control for accelerated of high sensitivity testing
  • Single-point electronic temperature calibration
  • Quick-release baskets for rapid sample loading, unloading and cleaning

Test Apparatus & Method of Tablet Disintegration

Before drug can dissolve into the blood stream, the tablet must first disintegrate into small particles.

Typically, the tablets and capsules to be tested are each placed in one of six vertical tubes each measuring approx. 77.5 mm long x 21 mm inside diameter, positioned in a circular basket  arrangement.

The lower end of each tube is covered by a 2 mm sieve mesh. Large tablets, capsules and boluses may require a larger basket. The basket assembly is raised and lowered in in a vessel containing 1000 mL of simulated gastric fluid at body temperature (37 °C) through a distance  of 55 mm, at a constant stroke frequency of 30 cycles per minute. A plastic disc of precise geometry “hammers” the tablet during the operation, thus assisting in the disintegration process. The tablet is said to pass the test providing that no tablet residue remains on the sieve mesh after the designated time, typically 30 minutes for ordinary tablets and 60 minutes for enteric-coated tablets.

 

 

DTGi Compliance & Maintenance

  • Certificate of compliance to Ph. Eur./USP provided as standard
  • Comprehensive IQ/OQ/PQ documentation packages and toolkits available
  • Passcode-protected single-point electronic temperature calibration
  • Latest temperature calibration information stored and available to print/export

 

Reporting

Extensive data output options are available as standard, including direct reporting to a printer or PC.

Data reporting output options:

  • USB A
  • USB B
  • RS 232 

Available Reporting Parameters

  • Speed (cycles per minute)
    – Set
    – Average
    – Maximum
    – Minimum
  • Temperature (°C)
    – Set
    – Average
    – Maximum
    – Minimum
  • Test Duration (HH:MM:SS)
    – Set
    – Actual
  • Calibration Data
    – Calibration date
    – Temperature calibrated at (°C)

 

Temperature Calibration

 Single-point electronic temperature calibration. Calibration of the DTGi Series temperature probe is simple, through the use of an electronic calibration  key and passcode-protected calibration menu designed to guide users through the process without fuss. The latest temperature probe calibration information is stored and available to print/export when convenient to the use.

 

Independent Station Control: DTG 200i-IS

With the same standard features as the other DTGi systems, the DTG 200i-IS offers independent control over each test station, making it ideal for the following types of applications:

  • Comparing one formulation directly against another
  • Comparing the performance of a single formulation under different conditions
  • Assessing delayed release or enteric coated tablets where samples must be immersed for specified periods of time in different media
  • Allowing two users to run tests simultaneously

 

DTGi System Accessories

Complete range of accessories for use with the DTGi Series is available, from complete basket-rack assemblies to individual tubes, discs and sieve meshes. All parts are manufactured to tolerances that are equal to or better than those quoted in the respective Pharmacopoeias. Certificates of  compliance can be supplied upon request.

For more details please click here >> to view the Disintegration Testing brochure

Pharmacopoeial Compliance:

 

Ph. Eur. 2.9.1

USP <701> and <2040>

User Interface

Resistive touchscreen

Basket Rack Assembly

Automatically lowered and raised at beginning and end of test run

Stroke Frequency Range

10 – 50 strokes/min

Stroke Height

55 ± 1 mm

Heater Type

Independent digital heater/circulator

Heater Temperature Range

Ambient – 50 °C

Test Run Time

Up to 99 hours , 59 minutes, 59 seconds

Alarm(s)

 

1. End of testing (audible)

 2. Low bath water level warning on-screen indicator

Data Output

RS 232

USB A (for connection with a USB printer)

USB B (for connection with a PC) 

 

DTG 100i

 

Number of Test Stations:

1

Tablet Capacity:

Up to 6

Independent Station Control:

No

Unit Dimensions (w x d x h):

450 x 473 x 657 mm

 

DTG 200i

 

Number of Test Stations:

2

Tablet Capacity:

Up to 12

Independent Station Control:

No

Unit Dimensions (w x d x h):

450 x 473 x 657 mm

 

DTG 300i

 

Number of Test Stations:

3

Tablet Capacity:

18

Independent Station Control:

No

Unit Dimensions (w x d x h):

700 x 473 x 657 mm

 

DTG 400i

 

Number of Test Stations:

4

Tablet Capacity:

24

Independent Station Control:

No

Unit Dimensions (w x d x h):

700 x 473 x 657 mm

 

DGT 200i IS

 

Number of Test Stations:

2

Tablet Capacity:

Up to 12

Independent Station Control:

Yes

Unit Dimensions (w x d x h):

515 x 473 x 657 mm

Click here to download Disintegration Testing brochure

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Home > Disintegration Apparatus

Location: IRELAND

Unit 21, Waterford Business Park,

Cork Road, Waterford

Ireland, X91 P224

Tel: +353 (0)51 392 391

E-mail: info@antech.ie

Contact: UK

Tel: +44 (0)20 346 898 13

E-mail: info@antechsolutions.co.uk

Web: www.antechsolutions.co.uk